old news
Superakiha | 2 years ago
Reply
old news
http://www.ncbi.nlm.nih.gov/pubmed/20152124
Neuron. 2010 Jan 28;65(2):165-77.
Enhancement of learning and memory by elevating brain magnesium.
Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Comment in:
* Neuron. 2010 Jan 28;65(2):143-4.
Abstract
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions. Copyright 2010 Elsevier Inc. All rights reserved.
cant buy it. could take tons of vitamin c and synthesize endogenously (threonic acid is vit c meabolite). could stack mag citrate with calcium threonate (cost prohibitive).
interesting. huh.
we give pregnant girls magnesium all the time for neuroprotetion.
Neuron. 2010 Jan 28;65(2):165-77.
Enhancement of learning and memory by elevating brain magnesium.
Slutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Comment in:
* Neuron. 2010 Jan 28;65(2):143-4.
Abstract
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions. Copyright 2010 Elsevier Inc. All rights reserved.
cant buy it. could take tons of vitamin c and synthesize endogenously (threonic acid is vit c meabolite). could stack mag citrate with calcium threonate (cost prohibitive).
interesting. huh.
we give pregnant girls magnesium all the time for neuroprotetion.
medicalstudent | 2 years ago
Reply
Stacking it wouldn't facilitate passage through the blood-brain barrier (it [threonate] wouldn't facilitate anything); -which is the purpose of compounding it, usually.
I'm not sure what 'endogenous' ...
sorry:/
Synthesis and Standard Enthalpy of Formation of Magnesium L-Threonate
Gao Sheng-Li;Yang Xu-Wu;Chen San-Ping;Ju Zhan-Feng
Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069
Abstract：
The white powder of magnesium L-threonate was obtained by extracting with alcohol the concentrated solution obtained from the reaction between L-threonic acid solution prepared by double decomposition reaction of calcium L-threonate with oxalic acid and superfluous magnesium oxide at 80 ℃. The composition of the new compound was determined by chemical and elemental analyses and its formula fits Mg(C4H7O5)2•H2O, the IR spectra indicated that Mg2＋ in the compound coordinates to oxygen atom of the carboxyl group, while the proton of the carboxyl group is dissociated, it was assumed that the coordination number of Mg2＋ was 4 . The results of TG－DTG showed that the compound had fairish stability, the intermediate and final product of the thermal decomposition of the compound are Mg(C4H7O5)2, Mg(CH3COO)2 and MgO, respectively. The constant volume combustion energy of the compound, ΔcE, was determined as (－10 407.34±4.67) kJ•mol－1 by a precise rotating-bomb calorimeter at 298.15 K, its standard enthalpies of combustion, ΔcHm, and standard enthalpies of formation, ΔfHm, were calculated as(－3 249.49±1.46) kJ•mol－1 and (－2 786.23±1.84) kJ•mol－1, respectively.
Keywords： Magnesium Lthreonate Synthesis Thermal analysis Standard enthalpies of formation
Received: 2002-02-10 Accepted: 2002-05-06 Online: 2002-11-15
Corresponding Authors: Gao Sheng-Li Email: gaoshli@nwu.edu.cn
Magnesium L-threonate(China (Mainland))
Magnesium L-threonate
L-Threonic acid Magnesium salt
CAS:778571-57-6
Molecular Formula C8H14MgO10
Molecular Weight 294.5
Appearance: white powder...
Min. Order: 1 Kilogram
Orchid Chemical Supplies Ltd
http://www.alibaba.com/product-gs/294858768/Magnesium_L_threonate.html
Bio-Sugars Technology Co.,Ltd. "Bio-sugars is pharmaceuticals and intermediates, especially on carbohydrate chemistry manufacturer. developed and diversified into many areas of carbohydrate research and synthesis. Many products involving carbohydrate building blocks can be supplied by us, such as D-arabinose,Calcium D-Arabonate, L-Arabinose, D-Galactose, Calcium L-Threonate,
Magnesium L-Threonate..."
I'm not sure what 'endogenous' ...
sorry:/
Synthesis and Standard Enthalpy of Formation of Magnesium L-Threonate
Gao Sheng-Li;Yang Xu-Wu;Chen San-Ping;Ju Zhan-Feng
Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, Xi’an 710069
Abstract：
The white powder of magnesium L-threonate was obtained by extracting with alcohol the concentrated solution obtained from the reaction between L-threonic acid solution prepared by double decomposition reaction of calcium L-threonate with oxalic acid and superfluous magnesium oxide at 80 ℃. The composition of the new compound was determined by chemical and elemental analyses and its formula fits Mg(C4H7O5)2•H2O, the IR spectra indicated that Mg2＋ in the compound coordinates to oxygen atom of the carboxyl group, while the proton of the carboxyl group is dissociated, it was assumed that the coordination number of Mg2＋ was 4 . The results of TG－DTG showed that the compound had fairish stability, the intermediate and final product of the thermal decomposition of the compound are Mg(C4H7O5)2, Mg(CH3COO)2 and MgO, respectively. The constant volume combustion energy of the compound, ΔcE, was determined as (－10 407.34±4.67) kJ•mol－1 by a precise rotating-bomb calorimeter at 298.15 K, its standard enthalpies of combustion, ΔcHm, and standard enthalpies of formation, ΔfHm, were calculated as(－3 249.49±1.46) kJ•mol－1 and (－2 786.23±1.84) kJ•mol－1, respectively.
Keywords： Magnesium Lthreonate Synthesis Thermal analysis Standard enthalpies of formation
Received: 2002-02-10 Accepted: 2002-05-06 Online: 2002-11-15
Corresponding Authors: Gao Sheng-Li Email: gaoshli@nwu.edu.cn
Magnesium L-threonate(China (Mainland))
Magnesium L-threonate
L-Threonic acid Magnesium salt
CAS:778571-57-6
Molecular Formula C8H14MgO10
Molecular Weight 294.5
Appearance: white powder...
Min. Order: 1 Kilogram
Orchid Chemical Supplies Ltd
http://www.alibaba.com/product-gs/294858768/Magnesium_L_threonate.html
Bio-Sugars Technology Co.,Ltd. "Bio-sugars is pharmaceuticals and intermediates, especially on carbohydrate chemistry manufacturer. developed and diversified into many areas of carbohydrate research and synthesis. Many products involving carbohydrate building blocks can be supplied by us, such as D-arabinose,Calcium D-Arabonate, L-Arabinose, D-Galactose, Calcium L-Threonate,
Magnesium L-Threonate..."
? | 2 years ago
Reply
wouldn't the Mg dissociate from threonate in the blood?
i'm limited in knowledge of brain Mg transport and homeostasis...
alibaba... niiiice detective work.
i'm limited in knowledge of brain Mg transport and homeostasis...
alibaba... niiiice detective work.
medicalstudent | 2 years ago
Reply
? | 2 years ago
Reply
[0260]The results suggest that the benefit of magnesium supplementation is not limited to cognitive function--it improves the overall health of the animal. It also suggests that there exists an optimal magnesium dosage range. Too high a dosage or a body magnesium level may diminish the benefit or even cause harm. Thus, this data also provides further support for establishing the optimal range of supplementation that yields health benefits.
Read more: http://www.faqs.org/patents/app/20080248137#ixzz0qRKtKs3g
Read more: http://www.faqs.org/patents/app/20080248137#ixzz0qRKtKs3g
? | 2 years ago
Reply
badass, thanks.
citrate seems best for now, marginal (~15%) elevation of csf magnesium. oxide could be worthless.
citrate seems best for now, marginal (~15%) elevation of csf magnesium. oxide could be worthless.
medicalstudent | 2 years ago
Reply
