dat involvement
dat involvement
1: Neurosci Lett. 2009 Oct 8. [Epub ahead of print]
Working Memory Plasticity Modulated by Dopamine Transporter Genotype.Brehmer Y, Westerberg H, Bellander M, Fürth D, Karlsson S, Bäckman L.
Aging Research Center, Karolinska Institute, Stockholm, Sweden.
Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received four weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.
signal - dopamine.
so, the question still remains, would cognitive training paired with dopaminergic drugs further enhance gains? maybe this correlation has to do with something other than the DAT specifically, but for now it seems more dopamine = more change.
dopamine = salience tagging = marker for repeat action
response - plasticity.
eat the salmon, pop the citicoline
again, sweden is on top of its' game. something tells me i'm part viking.
Working Memory Plasticity Modulated by Dopamine Transporter Genotype.Brehmer Y, Westerberg H, Bellander M, Fürth D, Karlsson S, Bäckman L.
Aging Research Center, Karolinska Institute, Stockholm, Sweden.
Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum. Compared to DAT1 9/10-repeat carriers, homozygosity of the DAT1 10-repeat allele has been related to less active dopaminergic pathways. A group of younger adults received four weeks of computerized adaptive training on several WM tasks. All participants improved their performance as a function of training. However, DAT1 9/10-repeat carriers showed larger training-related gains than DAT1 10-repeat carriers in visuospatial WM. By contrast, the two groups were indistinguishable in baseline WM performance as well as in a variety of tasks assessing different cognitive abilities. This pattern of results provides novel evidence that WM plasticity is a more sensitive indicator of DAT1 gene-related cognitive differences than single-assessment performance scores.
signal - dopamine.
so, the question still remains, would cognitive training paired with dopaminergic drugs further enhance gains? maybe this correlation has to do with something other than the DAT specifically, but for now it seems more dopamine = more change.
dopamine = salience tagging = marker for repeat action
response - plasticity.
eat the salmon, pop the citicoline
again, sweden is on top of its' game. something tells me i'm part viking.
medicalstudent | 2 years ago
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Dude, the autohagiography is uncalled for.
Anyway, you may want to read this: http://www.pnas.org/content/106/2/617.full
More dopamine wouldn't matter if the transporter (the very thing in question here) doesn't function efficiently as demonstrated in those with different alleles for the DAT1 gene.
As shown in this study, the answer to your question is a resounding "no".
Anyway, you may want to read this: http://www.pnas.org/content/106/2/617.full
More dopamine wouldn't matter if the transporter (the very thing in question here) doesn't function efficiently as demonstrated in those with different alleles for the DAT1 gene.
As shown in this study, the answer to your question is a resounding "no".
? | 2 years ago
Reply
