Nootropic Cypin
There have been a few studies in the past 5 years indicating cypin's role in dendrite formation...does anyone know of food sources or supplements that possibly increase cypin in the human brain? I can't find anything on it.
lostfalco | 2 years ago
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Yeah. I just bought some of this (just to see how it goes for a few months): hydergine.
Ergoloids (e.g. hydergine, LSD, ergometrine, bromocriptine) are known to stimulate neurogenic processes by promoting the release of the neurotrophic factor BDNF and upregulating transcription of the synaptic plasticity protein arc. Acute LSD has been shown to upregulate transcription of arc mRNA in the rat prefrontal cortex by upwards of three-fold (Nichols and Sanders-Bush, 2002; Nichols et al, 2003). Several ergoloids with dopaminergic agonist activity (bromocriptine, lisuride, LSD) have also been found to upregulate expression of the central anti-apoptotic protein Bcl-2 (Kihara et al, 2002; Caraci et al, 2005).
Read up on it.
Ergoloids (e.g. hydergine, LSD, ergometrine, bromocriptine) are known to stimulate neurogenic processes by promoting the release of the neurotrophic factor BDNF and upregulating transcription of the synaptic plasticity protein arc. Acute LSD has been shown to upregulate transcription of arc mRNA in the rat prefrontal cortex by upwards of three-fold (Nichols and Sanders-Bush, 2002; Nichols et al, 2003). Several ergoloids with dopaminergic agonist activity (bromocriptine, lisuride, LSD) have also been found to upregulate expression of the central anti-apoptotic protein Bcl-2 (Kihara et al, 2002; Caraci et al, 2005).
Read up on it.
? | 2 years ago
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I should qualify: it does that which seems to be related to cypin (increase dendrite formation and synaptic plasticity). But as for any specific relationship to cypin itself isn't altogether clear.
Here's an article on cypin http://www.nootropics.com/cypin/index.html
Here's an article on cypin http://www.nootropics.com/cypin/index.html
? | 2 years ago
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? | 2 years ago
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? | 2 years ago
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lostfalco | 2 years ago
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cypin seems to be an intracellular regulator of microtubule polymerization and subsequent dendritic arborization, regulating glutamate receptor scaffolding especially in hippocampal neurons.
this molecule is an elaborate downstream mediator of plastic change, many compounds probably regulate it (or its mRNA), we just haven't looked yet.
as a nootropic, this is far too specific and downstream. we need brain permeable compounds that modulate a symphony of compounds, including cypin.
this molecule is more pertinent to genetic engineering than one-off nootropism.
this molecule is an elaborate downstream mediator of plastic change, many compounds probably regulate it (or its mRNA), we just haven't looked yet.
as a nootropic, this is far too specific and downstream. we need brain permeable compounds that modulate a symphony of compounds, including cypin.
this molecule is more pertinent to genetic engineering than one-off nootropism.
medicalstudent | 2 years ago
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I was hoping that you might have some info about this...thanks medicalstudent. So, it sounds like I may have to wait about 35 years or so until genetic engineering is approved for healthy individuals. ha
So, what I'm actually looking for is the brain analog to protein for bodybuilders (I realize the whole "brain training" analogy is a VERY imperfect one so please bear with me). However, eating massive amounts of protein (in addition to getting your basic nutrition) at the right time combined with intense training over time allows one to gain 15-20 lbs of muscle per year. So, analogously if one were to train with dual n-back daily what would be the most likely candidate (beyond the basics of good sleep, exercise, and healthy diet) that would allow one to maximize results. I am looking more at building over time and not at some pill I take right before a test that is supposed to make me smarter instantly. What should I eat right before, during, and right after brain training exercises in order to maximally build my fluid intelligence over time (beyond the usual suspects of vitamins, minerals, etc.)? I'm guessing things like DHA, choline, or tyrosine/tryptophan might be the most likely choices, but I was wondering what you think. I realize the answer is almost certainly going to be some combination of things but I'm also curious if you had to pick only one what it would be. Is there something that can be eaten in massive quantities to build your brain like a body builder builds muscle? (Obviously you would want to do this within reasonable health constraints unlike muscle men who die of heart attacks at 38). Thanks for your insights.
So, what I'm actually looking for is the brain analog to protein for bodybuilders (I realize the whole "brain training" analogy is a VERY imperfect one so please bear with me). However, eating massive amounts of protein (in addition to getting your basic nutrition) at the right time combined with intense training over time allows one to gain 15-20 lbs of muscle per year. So, analogously if one were to train with dual n-back daily what would be the most likely candidate (beyond the basics of good sleep, exercise, and healthy diet) that would allow one to maximize results. I am looking more at building over time and not at some pill I take right before a test that is supposed to make me smarter instantly. What should I eat right before, during, and right after brain training exercises in order to maximally build my fluid intelligence over time (beyond the usual suspects of vitamins, minerals, etc.)? I'm guessing things like DHA, choline, or tyrosine/tryptophan might be the most likely choices, but I was wondering what you think. I realize the answer is almost certainly going to be some combination of things but I'm also curious if you had to pick only one what it would be. Is there something that can be eaten in massive quantities to build your brain like a body builder builds muscle? (Obviously you would want to do this within reasonable health constraints unlike muscle men who die of heart attacks at 38). Thanks for your insights.
lostfalco | 2 years ago
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You are exactly right. I have been focusing my efforts on figuring out the right combination of cognitive training that will induce long term structural changes in the brain that will allow make my waking state much clearer without the use of nootropics.
Nonetheless, I believe this goal will best be accomplished by using nootropics which enhance plasticity at the level of transcription. Currently the best two nootropics I have stumbled across in the literature and that seem the most promising are Noopept and Cerebrolysin.
These two drugs combined with a strict training regimen that provides lots of stimulation of the necessary neural networks and that allows for direct and immediate feedback appears to be the most promising. To this end, I have gone so far as to invest in the Emotiv Research edition EEG so that I can monitor which brainstates are conducive to my goals.
Two good articles on EEG training:
http://www.ncbi.nlm.nih.gov/sites/entrez
http://www.springerlink.com/content/r7mm5858l1835t24/
Article on Cerebrolysin:
http://sci.rutgers.edu/forum/showpost.php?p=437838 PUSH YOURSELF; KNOW WHAT YOUR TRAINING (you neeedfack); GIVE YOU BRAIN THE BEST NUTRIENTS (safe ones) SO THAT IT CAN GROW.
Nonetheless, I believe this goal will best be accomplished by using nootropics which enhance plasticity at the level of transcription. Currently the best two nootropics I have stumbled across in the literature and that seem the most promising are Noopept and Cerebrolysin.
These two drugs combined with a strict training regimen that provides lots of stimulation of the necessary neural networks and that allows for direct and immediate feedback appears to be the most promising. To this end, I have gone so far as to invest in the Emotiv Research edition EEG so that I can monitor which brainstates are conducive to my goals.
Two good articles on EEG training:
http://www.ncbi.nlm.nih.gov/sites/entrez
http://www.springerlink.com/content/r7mm5858l1835t24/
Article on Cerebrolysin:
http://sci.rutgers.edu/forum/showpost.php?p=437838 PUSH YOURSELF; KNOW WHAT YOUR TRAINING (you neeedfack); GIVE YOU BRAIN THE BEST NUTRIENTS (safe ones) SO THAT IT CAN GROW.
? | 2 years ago
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i took up recreational bodybuilding at about 14, so i know where you're coming from
first, the brain can adapt faster than the body. pfc protein synthesis seems to be required for wm strategy modification, but the amount and degree is likely much less than what is needed to increase muscular force. they are indeed similar, but only on a few fronts.
second, the way to facilitate cognitive gains through nootropism/diet is not currently known. conceivably, i see two ways this can be done. one is modulating the signal... i.e. neurotransmitter (dopamine, norepi, acetylcholine). candidate drug facilitators include anything working to augment transmitters in relevant cortical regions. the second way, and probably the much safer and sustainable way (abeit slower), is to modulate transmitter responsiveness. the signal is only as useful as the plastic change it induces. for this reason, exercise, DHA, citicoline, and trophic factor support should promote this kind of responsiveness.
ideally, you use both methods... and synergize.
if i could pick only one? citicoline (while eating alot of fatty fish)
the smarter you get, the smarter you need to be to move the needle further.
first, the brain can adapt faster than the body. pfc protein synthesis seems to be required for wm strategy modification, but the amount and degree is likely much less than what is needed to increase muscular force. they are indeed similar, but only on a few fronts.
second, the way to facilitate cognitive gains through nootropism/diet is not currently known. conceivably, i see two ways this can be done. one is modulating the signal... i.e. neurotransmitter (dopamine, norepi, acetylcholine). candidate drug facilitators include anything working to augment transmitters in relevant cortical regions. the second way, and probably the much safer and sustainable way (abeit slower), is to modulate transmitter responsiveness. the signal is only as useful as the plastic change it induces. for this reason, exercise, DHA, citicoline, and trophic factor support should promote this kind of responsiveness.
ideally, you use both methods... and synergize.
if i could pick only one? citicoline (while eating alot of fatty fish)
the smarter you get, the smarter you need to be to move the needle further.
medicalstudent | 2 years ago
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Thanks again! I started working out at about 14 as well so I am very aware of the huge difference diet can make. I've got the exercise, sleep, basic nutrition, and DHA going right now...I think I'll probably try the citicoline and see if I notice any change.
lostfalco | 2 years ago
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medicalstudent | 2 years ago
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Pardon my answering a question I wasn't asked, but here's a good list of (and discussion on) nootropics:
http://www.imminst.org/forum/index.php?showtopic=447
Brain enhancement is a highly individualized affair. Whatever one person says works may not work for another (YVMV). You are forced to experiment and do research on your own, essentially.
Take your brain into your own hands.
http://www.imminst.org/forum/index.php?showtopic=447
Brain enhancement is a highly individualized affair. Whatever one person says works may not work for another (YVMV). You are forced to experiment and do research on your own, essentially.
Take your brain into your own hands.
? | 2 years ago
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